Highway Patrol identified the victim of the crash as 65-year-old Kenneth Harris of Marshfield.
According to Highway Patrol, Harris was driving a 2003 Toyota Highlander westbound in the eastbound lanes of I-44 and struck a tracor-trailer head-on.
Harris was pronounced dead at the scene.
LACLEDE COUNTY, Mo. — Both the left and right lane on I-44 near Lebanon were temporarily closed due to a fatal accident.
Highway Patrol said the crash was between a tractor-trailer and an SUV.
Highway Patrol could not give the identity of the deceased.
Ozarks Traffic says the crash occurred at mile-marker 125.
Drivers can detour at Exit 123 for about two miles.
KOLR10 will post updates as they arrive.