It's being called "Earth, Wind, and Fire" and will involve full activation of the Springfield-Greene County Emergency Operations Center.
More than 20 agencies and dozens of volunteers will participate in the training, starting around 9:00 am.
The goal of the exercise is to find the strengths and weaknesses of the system and make improvements before a real disaster ever happens.
It will involve public health, environmental concerns, how deaths are handled and coordination between agencies.
Police, fire, both major hospitals, and emergency management will all play a role in the drill today.
Copyright 2016 Nexstar Broadcasting, Inc. All rights reserved. This material may not be published, broadcast, rewritten, or redistributed.