Rick Davis, who was elected mayor in April, was at his home at 303 Eighth Street when a fire broke out between 10:30 and 11 p.m., according to Pemiscot County Sheriff Tommy Greenwell.
Greenwell says the fire is believed to be accidental but an investigation is ongoing,
City hall is closed Thursday in light of Davis' death but the water office will be open, according to Caruthersville Assistant Police Chief Jerry Hudgens.
Hudgens says Sue Grantham will act as mayor pro tem.
Davis' wife was able to get out of the house and is expected to be okay.
The previous mayor of Caruthersville, Diane Sayre, also died in office, as did the next acting Mayor Pro Tem Frank Morgan.
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