The vehicle was traveling westbound on State Route NN, which is one mile east of Anderson, Mo. when it ran off the right side of road into a ditch and rolled over.
Aaron Schuler, 11, was transported by helicopter to Freeman Health System in Joplin where he was pronounced dead.
The driver, Barbara Schuler, 63, was also transported by helicopter to the hospital and is in serious condition.
Two other juvenile passengers suffered injuries in the crash.
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